Hormone Health MD Bioidentical Blog

July 10, 2008

Menopause and the Women’s Health Initiative Study

Filed under: bioidentical hormones,Menopause,Safety of Hormones — Dr. Bhuiya's Bioidentical Hormone Blog @ 6:43 am
Tags: , , , , , ,



Every day in the United States 3,500 women enter menopause.  Symptoms, however, can begin as long as fifteen years prior.  


          The normal age to go through menopause ranges from 35 to 55. Therefore, you may easily live one half of your life missing your hormones, and we age because we lose our hormones.


Until recently, the only hormonal therapy available in this country has been synthetic hormone replacement, that is, Premarin and Provera or Prempro.


          The government sponsored Women’s Health Initiative Program halted its study on Prempro, containing Premarin (horse urine estrogen) plus Provera, a progestin (synthetic progesterone, also called hydroxy-progesterone), on July 9, 2002.  This was three years early because of an increased risk of breast cancer in women taking this drug.


          The study revealed the following results:

· The stroke rate was 41 % higher in women taking Prempro 

· Women on Prempro had double the rate of blood clots.    

· Women on Prempro had an increase in breast cancer of 26%.

· Women on Prempro had a 22% increase in heart disease.


The results of the Women’s Health Initiative Study brought to the forefront why synthetic hormonal therapy will become a treatment of the past.


It is clear that Prempro increases the risk for disease and prompted the call for women to get off these synthetic hormones. Due to the above study Wyeth, the drug company that makes Prempro, has lost tremendous sales. Women and doctors have turned to a safe alternative which is bio-identical hormones. Wyeth’s loss of revenue has prompted the company to lobby for restrictions on compounding pharmacies to turn people back to using Prempro.


The safe alternative, bioidentical hormones: estradiol, progesterone, and testosterone, are all approved by the FDA in other medications at a set dose. The difference in compounding is that the dose is tailored to the patient’s needs through laboratory testing so they are not overdosed or under-dosed.


The recent Wyeth-provoked onslaught by the FDA on compounding pharmacies is the loophole that estriol, a weak estrogen present in the human body and often added to bio-identical estrogen compounds for breast cancer protection, is not in any FDA approved medications, but it is not necessary for treatment. Note that estriol is a part of the U.S. Pharmacopeia (USP).


The Wyeth-driven FDA also objected to compounding pharmacies using the term “bio-identical”.  What better term to describe substances that have the same exact molecular structures as those found in the human body (perhaps human-identical)?


The answer for hormone replacement is customized, safe, compounded, bio-identical hormone replacement that is a prescription issued in response to individual symptoms and laboratory analysis and tailored to the individual’s needs.


For further informattion contact

Aref Bhuiya M.D., 5655 Lindero Canyon Rd., Ste. 202, Westlake Village, CA 91362,


Blog at WordPress.com.